Gastrophysics: A network theory recipe book

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Skidology: Winter research that lets things slide

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2012 review: The year in health science

Read more: "2013 Smart Guide: 10 ideas that will shape the year"

The first half of 2012 will be remembered for the saga over whether or not to publish controversial research involving versions of the H5N1 bird flu virus engineered to spread more easily in mammals. In the end openness won out, and both contentious studies did finally see the light of day.

This was also the year that saw the battle to eradicate polio reach its crucial endgame – just as another problem, in the form of totally drug resistant tuberculosis, reared its head.

Away from infectious disease, 2012 brought us a theory on the link between Tutankhamun, epilepsy and the first monotheistic religion, and an insight into the perils of premature ageing in Italy's ominously named Triangle of Death. Here are 10 more of the year's memorable stories.

Babies are born dirty, with a gutful of bacteria
Far from being sterile, babies come complete with an army of bacteria. The finding could have implications for gut disorders and our health in general

Forensic failure: 'Miscarriages of justice will occur'
Our survey of UK forensic scientists reveals that many are concerned that closure of the Forensic Science Service will lead to miscarriages of justice

Scandal of an underfunded and undertreated cancer
Lung cancer in those who have never smoked is on the rise – but they face the same stigma as their smoking counterparts

Ovarian stem cells discovered in humans
Stem cells capable of forming new eggs could promise limitless eggs for IVF treatments, and the rejuvenation of older eggs

Paralysis breakthrough: spinal cord damage repaired
An implant helping paralysed people stand unaided suggests the spinal cord is able to recover function years after severe damage

A real fMRI high: My ecstasy brain scan
Graham Lawton reports the highs, lows and psychedelic purple doors involved in taking MDMA while having his brain scanned

You may carry cells from siblings, aunts and uncles
Male cells found in the umbilical cord blood of baby girls with older brothers suggests fetal cells cross between mother and baby more than once thought

Can we deter athletes who self-harm to win?
The Paralympics may encourage a debate on a dangerous practice – and potential ways to prevent it

First non-hormonal male 'pill' prevents pregnancy
A non-hormonal drug that temporarily reverses male fertility appears to have few side effects in mice

Mining MRSA genetic code halts superbug outbreak
Whole genome sequencing of an MRSA outbreak has identified the person who unwittingly spread the bacteria around a hospital, stopping further infection

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Getting sloshed: It's the way you walk

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Today on New Scientist: 28 December 2012

Best videos of 2012: Rare view of Challenger tragedy

Watch a rare amateur video of the Challenger explosion, our most-viewed video of the year

Strong jet stream super-charged US Christmas storms

Record snowfall and dozens of tornadoes snarled holiday travel as a powerful winter storm plowed across much of the US, while rainstorms battered the UK

2012 review: The year in life science

The year's biggest stories in life science, including James Cameron's descent into the Mariana trench and efforts to break into Antarctica's buried lakes

Superstorm lessons for adapting to climate change

As the post-Sandy rebuild gets under way, coastal cities around the world will be watching

Best videos of 2012: First MRI movie of childbirth

Watch a unique view of a baby's birth, at number 2 in our countdown of the year's top science videos

Fleadom or death: Reviving the glorious flea circus

The parasite-based sideshows were almost done for by the domestic vacuum cleaner - but they are bouncing back, finds Graham Lawton

Approval for gene-modified salmon spawns controversy

Apparently months late, US regulators have declared genetically engineered fish safe to farm and eat, but final approval could be some way off

Best videos of 2012: New aircraft flies inside out

Watch a novel flying machine use a unique mechanism to propel itself, at number 3 in our countdown of the top videos of the year

2012 review: The year in technology

The year's biggest stories in technology, including Kinect devices that may spot signs of autism and controlling a robot by the power of thought

Superdoodles: The science of scribbling

Far from being a distraction, doodling has an important purpose - and you can harness it

2013 Smart Guide: Wave goodbye to the mouse

The Leap, a 3D motion control device set to launch next year, will let you control your computer with touch-free hand and finger movements

Read More..

Today on New Scientist: 28 December 2012

Best videos of 2012: Rare view of Challenger tragedy

Watch a rare amateur video of the Challenger explosion, our most-viewed video of the year

Strong jet stream super-charged US Christmas storms

Record snowfall and dozens of tornadoes snarled holiday travel as a powerful winter storm plowed across much of the US, while rainstorms battered the UK

2012 review: The year in life science

The year's biggest stories in life science, including James Cameron's descent into the Mariana trench and efforts to break into Antarctica's buried lakes

Superstorm lessons for adapting to climate change

As the post-Sandy rebuild gets under way, coastal cities around the world will be watching

Best videos of 2012: First MRI movie of childbirth

Watch a unique view of a baby's birth, at number 2 in our countdown of the year's top science videos

Fleadom or death: Reviving the glorious flea circus

The parasite-based sideshows were almost done for by the domestic vacuum cleaner - but they are bouncing back, finds Graham Lawton

Approval for gene-modified salmon spawns controversy

Apparently months late, US regulators have declared genetically engineered fish safe to farm and eat, but final approval could be some way off

Best videos of 2012: New aircraft flies inside out

Watch a novel flying machine use a unique mechanism to propel itself, at number 3 in our countdown of the top videos of the year

2012 review: The year in technology

The year's biggest stories in technology, including Kinect devices that may spot signs of autism and controlling a robot by the power of thought

Superdoodles: The science of scribbling

Far from being a distraction, doodling has an important purpose - and you can harness it

2013 Smart Guide: Wave goodbye to the mouse

The Leap, a 3D motion control device set to launch next year, will let you control your computer with touch-free hand and finger movements

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Superdoodles: The science of scribbling

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Shiver me timbers: the coolest warship ever made

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2013 Smart Guide: Hot computing for a cool billion

Read more: "2013 Smart Guide: 10 ideas that will shape the year"

It has been called science's X Factor: six mega-projects vying for two prizes, each worth a cool €1 billion.

In 2010, the European Commission put out a call for visionary computing initiatives comparable to the moon landing or the mapping of the human genome. Such ultra-ambitious projects would change the way we think about the world and ideally solve some of its problems, too.

Of 21 ideas submitted, six were shortlisted for further development. These include the Human Brain Project - an attempt to simulate the brain using a supercomputer - and a scheme to create a new generation of electronic devices based not on silicon but graphene.

The winners will be announced at the end of January. The prize money, from European countries and private firms as well as the European Union, will be spread over 10 years.

Our money is on FuturICT, a real-life SimCity on a global scale. It will give individuals, companies and governments real-time information about the planet, and run simulations to find the best strategies for dealing with issues such as climate change.

FuturICT was conceived after the 2008 financial crash drove home our lack of understanding about today's hyperconnected world. The civilisation simulator will be an open platform, accepting data on anything from social media and the stock exchange to climate models and political preferences. Stay tuned for the start of something big.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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New Scientist 2012 holiday quiz

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THIS was the year we held our breath in almost unbearable anticipation while we waited to see whether physicists at the Large Hadron Collider would finally get a clear view of the Higgs boson, so tantalisingly hinted at last December. Going a bit blue, we held on through March when one of the LHC's detectors seemed to lose sight of the thing, before exhaling in a puff of almost-resolution in July, when researchers announced that the data added up to a fairly confident pretty-much-actual-discovery of the particle.

Early indications were that it might be a weird and wonderful variety of the Higgs, prompting a collective gasp of excitement. That was followed by a synchronised sigh of mild disappointment when later data implied that it was probably the most boring possible version after all, and not a strange entity pointing the way to new dimensions and the true nature of dark matter. Prepare yourself for another puff or two as the big story moves on next year.

This respirational rollercoaster might be running a bit too slowly to supply enough oxygen to the brain of a New Scientist reader, so we have taken care to provide more frequent oohs and aahs using less momentous revelations. See how many of the following unfundamental discoveries you can distinguish from the truth-free mimics that crowd parasitically around them.

1. Which of these anatomical incongruities of the animal kingdom did we describe on 14 July?

• a) A fish, found in a canal in Vietnam, that wears its genitals under its mouth
• b) A frog, found in a puddle in Peru, that has no spleen
• c) A lizard, found in a cave in Indonesia, that has four left feet
• d) A cat, found in a tree in northern England, that has eight extra teeth

2. "A sprout by any other name would taste as foul." So wrote William Shakespeare in his diary on 25 December 1598, setting off the centuries of slightly unjust ridicule experienced by this routinely over-cooked vegetable. But which forbiddingly named veg did we report on 7 July as having more health-giving power than the sprout, its active ingredient being trialled as a treatment for prostate cancer?

• a) Poison celery
• b) Murder beans
• c) Inconvenience potatoes
• d) Death carrots

3. Scientists often like to say they are opening a new window on things. Usually that is a metaphor, but on 10 November we reported on a more literal innovation in the fenestral realm. It was:

• a) A perspex peephole set in the nest of the fearsome Japanese giant hornet, to reveal its domestic habits
• b) A glass porthole implanted in the abdomen of a mouse, to reveal the process of tumour metastasis
• c) A crystal portal in the inner vessel of an experimental thorium reactor, to reveal its nuclear fires to the naked eye
• d) A small window high on the wall of a basement office in the Princeton physics department, to reveal a small patch of sky to postgraduate students who have not been outside for seven years

4. On 10 March we described a new material for violin strings, said to produce a brilliant and complex sound richer than that of catgut. What makes up these super strings?

• a) Mousegut
• b) Spider silk
• c) Braided carbon nanotubes
• d) An alloy of yttrium and ytterbium

5. While the peril of climate change looms inexorably larger, in this festive-for-some season we might take a minute to look on the bright side. On 17 March we reported on one benefit of global warming, which might make life better for some people for a while. It was:

• a) Receding Arctic sea ice will make it easier to lay undersea cables to boost internet speeds
• b) Increasing temperatures mean that Greenlanders can soon start making their own wine
• c) Rising sea levels could allow a string of new beach resorts to open in the impoverished country of Chad
• d) More acidic seawater will add a pleasant tang to the salt water taffy sweets made in Atlantic City

6. In Alaska's Glacier Bay national park, the brown bear in the photo (above, right) is doing something never before witnessed among bearkind, as we revealed on 10 March. Is it:

• a) Making a phonecall?
• b) Gnawing at a piece of whalebone to dislodge a rotten tooth?
• c) Scratching itself with a barnacle-covered stone tool?
• d) Cracking oysters on its jaw?

7. Men have much in common with fruit flies, as we revealed on 24 March. When the sexual advances of a male fruit fly are rejected, he may respond by:

• a) Whining
• b) Hitting the booze
• c) Jumping off a tall building
• d) Hovering around the choosy female long after all hope is lost

8. While great Higgsian things were happening at the LHC, scientists puzzled over a newly urgent question: what should we call the boson? Peter Higgs wasn't the only physicist to predict its existence, and some have suggested that the particle's name should also include those other theorists or perhaps reflect some other aspect of the particle. Which of the following is a real suggestion that we reported on 24 March?

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If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Review of 2012: The year's biggest news at a glance

Halt to bird flu experiments, Greece's economic crisis, the Stuxnet computer worm, Curiosity arrives on Mars, and more

Read more: "2013 Smart Guide: 10 ideas that will shape the year"

January

Flu researchers announce a temporary halt on H5N1 bird flu experiments amid ongoing controversy over whether the benefits outweigh the potential risks.

Wikipedia stages a 24-hour blackout in protest against two copyright bills going through the US Congress.

February

Stem cells are discovered in human ovaries, suggesting that new eggs are created throughout a woman's life. The finding could one day enhance IVF treatments.

Last year's shocking result that neutrinos apparently travelled faster than the speed of light may actually have been due to a faulty fibre-optic cable, says CERN.

March

Sabu, the world's most notorious computer hacker and leader of LulzSec, is exposed as an FBI informant.

April

Synthetic biologists discover that six other molecules, not just DNA, can store and pass on genetic information.

May

Economic crisis leaves Greece on the brink of a humanitarian disaster as savage austerity measures spark violent street protests.

June

The Stuxnet computer worm that wrecked Iran's nuclear facilities is revealed to be a US cyberweapon, launched by the Bush administration and later endorsed by President Obama.

July

Particle physics makes headline news around the world as a team at CERN announces that the Higgs boson may have been discovered. The world's most sought-after particle, which gives all elementary particles mass, was spotted by sifting through the debris of trillions of collisions between protons within the ATLAS and CMS detectors at CERN's Large Hadron Collider (see photo). The discovery comes almost 50 years after Peter Higgs predicted the boson existed.

August

NASA's rover, Curiosity, arrives on Mars in the most ambitious and complicated space landing ever made.

September

Arctic sea ice shrinks to a record low. If the decline continues, by the 2050s Arctic summers could be ice-free for the first time in 3 million years.

October

Hurricane Sandy crashes into the east coast of the US, causing widespread devastation and power cuts, and leaving huge swathes of New York under water.

Felix Baumgartner leaps from a balloon 39km above the Earth and becomes the first skydiver to break the speed of sound in free fall.

November

President Obama is re-elected after a campaign that saw micro-targeting of voters using social media. The result was predicted by statistician Nate Silver.

Europe will face more floods and higher temperatures as the effects of climate change worsen, a new report warns.

December

The first analysis of soil on Mars by the Curiosity rover reveals a mysterious carbon compound.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Today on New Scientist: 21 December 2012

Cadaver stem cells offer new hope of life after death

Stem cells can be extracted from bone marrow five days after death to be used in life-saving treatments

Apple's patents under fire at US patent office

The tech firm is skating on thin ice with some of the patents that won it a $1 billion settlement against Samsung

Himalayan dam-building threatens endemic species

The world's highest mountains look set to become home to a huge number of dams - good news for clean energy but bad news for biodiversity

Astrophile: Black hole exposed as a dwarf in disguise

A white dwarf star caught mimicking a black hole's X-ray flashes may be the first in a new class of binary star systems

Blind juggling robot keeps a ball in the air for hours

The robot, which has no visual sensors, can juggle a ball flawlessly by analysing its trajectory

Studio sessions show how Bengalese finch stays in tune

This songbird doesn't need technological aids to stay in tune - and it's smart enough to not worry when it hears notes that are too far off to be true

Giant tooth hints at truly monumental dinosaur

A lone tooth found in Argentina may have belonged to a dinosaur even larger than those we know of, but what to call it?

Avian flu virus learns to fly without wings

A strain of bird flu that hit the Netherlands in 2003 travelled by air, a hitherto suspected by unproven route of transmission

Feedback: Are wind turbines really fans?

A tale of "disease-spreading" wind farms, the trouble with quantifying "don't know", the death of parody in the UK, and more

The link between devaluing animals and discrimination

Our feelings about other animals have important consequences for how we treat humans, say prejudice researchers Gordon Hodson and Kimberly Costello

Best videos of 2012: First motion MRI of unborn twins

Watch twins fight for space in the womb, as we reach number 6 in our countdown of the top videos of the year

2012 Flash Fiction winner: Sleep by Richard Clarke

Congratulations to Richard Clarke, who won the 2012 New Scientist Flash Fiction competition with a clever work of satire

Urban Byzantine monks gave in to temptation

They were supposed to live on an ascetic diet of mainly bread and water, but the monks in 6th-century Jerusalem were tucking into animal products

The pregnant promise of fetal medicine

As prenatal diagnosis and treatment advance, we are entering difficult ethical territory

2013 Smart Guide: Searching for human origins in Asia

Africa is where humanity began, where we took our first steps, but those interested in the latest cool stuff on our origins should now look to Asia instead

The end of the world is an opportunity, not a threat

Don't waste time bemoaning the demise of the old order; get on with building the new one

Victorian counting device gets speedy quantum makeover

A photon-based version of a 19th-century mechanical device could bring quantum computers a step closer

Did learning to fly give bats super-immunity?

When bats first took to the air, something changed in their DNA which may have triggered their incredible immunity to viruses

Van-sized space rock is a cosmic oddball

Fragments from a meteor that exploded over California in April are unusually low in amino acids, putting a twist on one theory of how life on Earth began

Read More..

Today on New Scientist: 21 December 2012

Cadaver stem cells offer new hope of life after death

Stem cells can be extracted from bone marrow five days after death to be used in life-saving treatments

Apple's patents under fire at US patent office

The tech firm is skating on thin ice with some of the patents that won it a $1 billion settlement against Samsung

Himalayan dam-building threatens endemic species

The world's highest mountains look set to become home to a huge number of dams - good news for clean energy but bad news for biodiversity

Astrophile: Black hole exposed as a dwarf in disguise

A white dwarf star caught mimicking a black hole's X-ray flashes may be the first in a new class of binary star systems

Blind juggling robot keeps a ball in the air for hours

The robot, which has no visual sensors, can juggle a ball flawlessly by analysing its trajectory

Studio sessions show how Bengalese finch stays in tune

This songbird doesn't need technological aids to stay in tune - and it's smart enough to not worry when it hears notes that are too far off to be true

Giant tooth hints at truly monumental dinosaur

A lone tooth found in Argentina may have belonged to a dinosaur even larger than those we know of, but what to call it?

Avian flu virus learns to fly without wings

A strain of bird flu that hit the Netherlands in 2003 travelled by air, a hitherto suspected by unproven route of transmission

Feedback: Are wind turbines really fans?

A tale of "disease-spreading" wind farms, the trouble with quantifying "don't know", the death of parody in the UK, and more

The link between devaluing animals and discrimination

Our feelings about other animals have important consequences for how we treat humans, say prejudice researchers Gordon Hodson and Kimberly Costello

Best videos of 2012: First motion MRI of unborn twins

Watch twins fight for space in the womb, as we reach number 6 in our countdown of the top videos of the year

2012 Flash Fiction winner: Sleep by Richard Clarke

Congratulations to Richard Clarke, who won the 2012 New Scientist Flash Fiction competition with a clever work of satire

Urban Byzantine monks gave in to temptation

They were supposed to live on an ascetic diet of mainly bread and water, but the monks in 6th-century Jerusalem were tucking into animal products

The pregnant promise of fetal medicine

As prenatal diagnosis and treatment advance, we are entering difficult ethical territory

2013 Smart Guide: Searching for human origins in Asia

Africa is where humanity began, where we took our first steps, but those interested in the latest cool stuff on our origins should now look to Asia instead

The end of the world is an opportunity, not a threat

Don't waste time bemoaning the demise of the old order; get on with building the new one

Victorian counting device gets speedy quantum makeover

A photon-based version of a 19th-century mechanical device could bring quantum computers a step closer

Did learning to fly give bats super-immunity?

When bats first took to the air, something changed in their DNA which may have triggered their incredible immunity to viruses

Van-sized space rock is a cosmic oddball

Fragments from a meteor that exploded over California in April are unusually low in amino acids, putting a twist on one theory of how life on Earth began

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Urban Byzantine monks gave in to temptation

WHO ate all the pies? In 6th-century Jerusalem, the Byzantine monks were greedy gobblers - despite strict rules that they should eat mainly bread and water.

Most early Byzantine monasteries were located in remote deserts, but St Stephen's monastery thrived in Jerusalem. Wondering how urban living affected the monks, Lesley Gregoricka at the University of South Alabama in Mobile took bone samples from 55 skeletons buried under the monastery.

The ratios of various isotopes of carbon and nitrogen in the bones confirmed that the monks ate a lot of common cereals like wheat, as well as fruit and vegetables. But many bones were rich in the heavy isotope nitrogen-15, suggesting the monks ate lots of animal protein. That could mean meat, or dairy products such as cheese (Journal of Anthropological Archaeology, doi.org/jzt).

"The rules on issues such as poverty, chastity and obedience were certainly known and could not be easily ignored," says Peter Hatlie of the University of Dallas's Rome Program in Frattocchie, Italy. "Only fallen, weak, mad and demonic monks ate meat."

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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2013 Smart Guide: New maps to rein in cosmic inflation

Read more: "2013 Smart Guide: 10 ideas that will shape the year"

We're about to get a better grasp of one of the biggest ideas in the universe: inflation. The first maps of the cosmos from the European Space Agency's Planck satellite are due out in early 2013. They should help us to hone descriptions of how, after the big bang, the universe grew from smaller than a proton into a vast expanse in less than a trillionth of a trillionth of a second.

The early universe was a featureless soup of hot plasma that somehow grew into the dense galaxy clusters and cosmic voids we know today. On a large scale, regions far apart from each other should look very different, according to the laws of thermodynamics. But studies of the cosmic microwave background (CMB) - the first light to be released, some 300,000 years after the big bang - show that the universe still looks virtually the same in all directions.

To explain this unlikely sameness, physicists invoked inflation: since all points in the universe were once next-door neighbours, the idea is that they blew apart so quickly that they couldn't forget about each other. Data from NASA's Wilkinson Microwave Anisotropy Probe (WMAP), launched in 2001, bolstered a key prediction of inflation, that the universe's structure was seeded by quantum fluctuations in space-time.

Stephen Hawking recently told New Scientist that WMAP's evidence for inflation was the most exciting development in physics during his career. But a best-fit model for what drove the exponential expansion, when it began and how long it lasted, hasn't been agreed. The WMAP data also revealed some surprises, such as inexplicable patterns in the CMB. So cosmologists have been anxiously awaiting Planck's higher-resolution maps to set the record straight. The Planck team will release its first cosmological results from 15 months' worth of data in March.

In addition, the Planck results will help refine figures for how much dark energy, dark matter and normal matter make up the universe. Planck might also record the first direct signs of ripples in space-time called gravitational waves. Not bad for a probe that's already half dead - one of Planck's two detectors stopped working in January. The entire craft will be shuttered in August.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

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App for quizzing your way to being a mastermind

Software that harnesses principles of cognitive science aims to turn you into a grade-A student

YOU are walking down the street when your phone buzzes. "What is the capital of Maryland?" it asks you. You know the answer but you can't quite grasp it until all of a sudden you remember: "Annapolis". The question prompted your brain just in time.

That is the scenario envisaged by the makers of software Cerego, which launched last week. It uses a basic principle of cognitive science called "spaced repetition" to improve learning. To remember something long term, a student must return to it several times, increasing the interval between each revision. The concept isn't new, but Cerego aims to harness the idea to let people learn anytime, anywhere.

"The amount of information we need to retain is growing rapidly," says Cerego co-founder Andrew Smith Lewis. "Current solutions do a fine job of bringing information to the screen, but we're not seeing much on how we learn." Smith Lewis says Cerego's grand ambition is to "handle learning and relearning for the duration of the user's lifetime".

From the moment you log on to Cerego on a tablet or PC, the software tracks every move you make, learning about you: how long you take to answer questions, how much faster you answer when you've seen a question before, which questions you skip and which questions you get wrong. That information is analysed to work out when you next need to see each piece of information. If you quickly and correctly give the capital of Maryland, for example, the system might wait two or three days before quizzing you on that fact again, and then double the interval after another correct answer. If you are wrong, the item may come up every few minutes until you improve.

"It's all very plausible and reasonable. They know their literature," says Ryan Baker, an educational technology researcher at Worcester Polytechnic Institute in Massachusetts. "I haven't seen any commercial products that put together all these different things."

Cerego doesn't yet have any published results to back up the claims made for the product. But Smith Lewis says they are working on this, and points to preliminary tests on language acquisition, run over five weeks at the University of Hawaii and reviewed by Cerego's scientific adviser, Jan Plass at New York University. In those tests, users improved their retention of factual material by a factor of three compared to a visually identical system that didn't run the spacing algorithm.

Another company, Carnegie Learning, has a different approach. Rather than concentrating on the time intervals between learning, Carnegie wants to improve how students grasp mathematics by helping them break down complex processes into chains of individual principles. Such "procedural learning" is something the brain does anyway.

Carnegie's method analyses each step a student takes while solving a maths problem. If they make a mistake, it recommends more study in the specific mathematical operation they are weak in. The idea is to reinforce a particular step in the process, as well as the principles behind it.

"There is this tremendous potential to optimise human learning," says Ken Koedinger, a co-founder of Carnegie Learning in Pittsburgh, Pennsylvania. Computational aids that target how we absorb information - like spaced repetition or procedural learning - should improve our capacity for learning. At the moment, Cerego works only for lists of facts, like state capitals, but its makers plan to expand it to become a platform for learning anything, from recipes to the complex skills required for jobs like flying a plane.

Smith Lewis says the company plans to use the data it gathers on its students to offer a certification service, allowing users to show off what they know to employers, for example.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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'The idea we live in a simulation isn't science fiction'

If the universe is just a Matrix-like simulation, how could we ever know? Physicist Silas Beane thinks he has the answer

The idea that we live in a simulation is just science fiction, isn't it?
There is a famous argument that we probably do live in a simulation. The idea is that in future, humans will be able to simulate entire universes quite easily. And given the vastness of time ahead, the number of these simulations is likely to be huge. So if you ask the question: 'do we live in the one true reality or in one of the many simulations?', the answer, statistically speaking, is that we're more likely to be living in a simulation.

How did you end up working on this issue?
My day job is to do high performance computing simulations of the forces of nature, particularly the strong nuclear force. My colleagues and I use a grid-like lattice to represent a small chunk of space and time. We put all the forces into that little cube and calculate what happens. In effect, we're simulating a very tiny corner of the universe.

How accurate are your simulations?
We're able to calculate some of the properties of real things like the simplest nuclei. But the process also generates artefacts that don't appear in the real world and that we have to remove. So we started to think about what sort of artefacts might appear if we lived in a simulation.

What did you discover?
In our universe the laws of physics are the same in every direction. But in a grid, this changes since you no longer have a spacetime continuum, and the laws of physics would depend on direction. Simulators would be able to hide this effect but they wouldn't be able to get rid of it completely.

How might we gather evidence that we're in a simulation?
Using very high energy particles. The highest energy particles that we know of are cosmic rays and there is a well-known natural cut off in their energy at about 10²⁰ electron volts. We calculated that if the simulators used a grid size of about 10^-27 metres, then the cut off energy would vary in different directions.

Do cosmic rays vary in this way?
We don't know. The highest energy cosmic rays are very rare. A square kilometre on Earth is hit by one only about once per century so we're not going to be able map out their distribution any time soon. And even if we do, it'll be hard to show that this is conclusive proof that we're in a simulation.

But can we improve our own simulations?
The size of the universe we simulate is a just fermi, that's a box with sides 10^-15 metres long. But we can use Moore's Law to imagine what we might be able to simulate in future. If the current trends in computing continue, we should be simulating a universe the size of a human within a century and within five centuries, we could manage a box 10²⁶ metres big. That's the size of the observable universe.

How have people reacted to your work?
I gave a lecture on this topic the other week and the turnout was amazing. Half of the people looked at me as if I was disturbed and the other half were very enthusiastic.

Profile

Silas Beane is a physicist at the University of Bonn, Germany. His paper "Constraints on the Universe as a Numerical Simulation" has been submitted to the journal Physical Review D

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How human biology can prevent drug deaths

Thousands of people die from adverse effects of medicines that have been tested on animals. There is a better way, say geneticist Kathy Archibald and pharmacologist Robert Coleman

ADVERSE drug reactions are a major cause of death, killing 197,000 people annually in the European Union and upwards of 100,000 in the US. Little coverage is given to such grim statistics by governments or pharmaceutical companies, so patients and their doctors are not primed to be as vigilant as they should be, and adverse drug reactions (ADRs) remain seriously under-recognised and under-reported.

The €5.88-million EU-ADR project, which published its final report in October, showed that it is possible to spot these reactions earlier by applying data-mining techniques to electronic health records. These techniques could, for example, have detected the cardiovascular risk signals of arthritis drug Vioxx three years before the drug was withdrawn in 2004 - saving many tens of thousands of lives. But invaluable as such systems are, it would be even better to detect risk signals before a drug reaches humans, thus saving even more lives.

Currently, 92 per cent of new drugs fail clinical trials, even though they have successfully passed animal tests. This is mostly because of toxicity, which can be serious and even fatal for the people taking part in the trials. For example, in 2006, six people enrolled in a UK trial of the drug TGN1412 were hospitalised after developing multiple organ failure. Many clinical trials are now conducted in India, where, according to India's Tribune newspaper, at least 1725 people died in drug trials between 2007 and 2011. Clearly, there is an urgent need for better methods to predict the safety of medicines for patients as well as volunteers in clinical trials.

At the patient safety charity, Safer Medicines, we believe this goal is most likely to be achieved through a greatly increased focus on human, rather than animal, biology in preclinical drugs tests. New tests based on human biology can predict many adverse reactions that animal tests fail to do, and could, for example, have detected the risk signals produced by Vioxx, which in animal studies appeared to be safe, and even beneficial to the heart.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed "patient in a dish"); "body on a chip" devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy. Then there are the more humble but no less valuable studies in ethically donated "waste" tissue.

These innovations promise precious insights into the functioning of the integrated human system. Many are already commercially available, but they are not being embraced with the enthusiasm they merit.

Pharmaceutical companies would make much greater use of them if governments encouraged it, but inflexible requirements for animal tests is a major deterrent. Ever since the thalidomide birth-defects tragedy, animal testing has been enshrined in law worldwide, despite the irony that more animal testing would not have prevented the release of thalidomide, because the drug harms very few species.

So how well have animal tests protected us? Many studies have calculated the ability of animal tests to predict adverse reactions to be at or below 50 per cent. In 2008, a study in Theriogenology (vol 69, p 2) concluded: "On average, the extrapolated results from studies using tens of millions of animals fail to accurately predict human responses." And a recent study in Regulatory Toxicology and Pharmacology (vol 64, p 345) shows that animal tests missed 81 per cent of the serious side effects of 43 drugs that went on to harm patients.

It is hard to understand why governments defend a system with such a poor record, or why they are dismissive of new technologies that promise increased patient safety while decreasing the time and cost of drug development, not to mention the savings to healthcare systems from fewer adverse drug reactions. Proposals to compare human-based tests with animal-based approaches have been strongly supported by members of the UK parliament. The Early Day Motions they signed were among the most-signed of all parliamentary motions between 2005 and 2006, 2008 and 2009, and 2010 and 2012.

Safer Medicines has put these concerns to the UK Department of Health and the prime minister - to be told that "human biology-based tests are not better able to predict adverse drug reactions in humans than animal tests".

It is a tragedy that so many suffer or die through the use of inadequately tested drugs when tests based on human biology are readily available. Yet governments continue to mandate animal tests, despite the lack of a formal demonstration of fitness for purpose, and a growing global realisation among scientists that animal toxicity tests are inadequate and must be replaced.

In its 2007 report, Toxicity Testing in the 21st Century: A Vision and a Strategy, the US National Research Council called for the replacement of animal tests: "The vision for toxicity testing in the 21st century articulated here represents a paradigm shift from the use of experimental animals... toward the use of more efficient in vitro tests and computational techniques." To its credit, the US government is at least working on initiatives to hasten this. The UK government, however, still denies there is a problem. How many must die before it listens?

Kathy Archibald is director of the Safer Medicines Trust. She is a geneticist who worked in the pharmaceutical industry.

Robert Coleman is a pharmacologist with pharmaceutical industry experience. He is now a drug discovery consultant and adviser to the trust

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Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

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CERN becomes first pure physics voice in UN chorus

Lisa Grossman, physical sciences reporter

(Image: UN Photo/Paulo Filgueiras)

If CERN observes the proceedings of the United Nations, will it change the outcome?

The international particle physics laboratory, based near Geneva, Switzerland, has been granted observer status in the General Assembly of the United Nations, CERN officials announced today. 

The lab joins environmental groups and public health agencies as the first physical sciences research organization in the ranks of UN observers. Observer status grants the right to speak at meetings, participate in procedural votes, and sign and sponsor resolutions, but not to vote on resolutions.

In some ways, CERN's addition seems a natural move - and a long time coming.

The facility was founded in 1954 under the auspices of the United Nations Educational, Scientific and Cultural Organisation (UNESCO). Its initial mission was to provide collaborative projects for researchers from Allied countries and former Axis countries after the second World War.

Arguably the lab's most high-profile project, the Large Hadron Collider, made headlines worldwide this year when it revealed detection of a new particle that appears to be the elusive Higgs boson.

"Through its projects, which bring together scientists from all over the world, CERN also promotes dialogue between nations and has become a model for international cooperation," CERN states in a press release. The lab says it may use its new status with the UN to help shore up scientific education and technological capabilities in developing countries, particularly in Africa.

But just as observing a quantum particle can change its state, can CERN's involvement truly collapse the UN's wavefunction and trigger better global science and technology policies? Only time will tell.

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